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For current pricing, see our [semaglutide cost guide](/guides/semaglutide-cost-price-guide-2026).* --- ## References - [Ozempic (semaglutide) Prescribing Information]( *Novo Nordisk / FDA*, 2024
Unlike semaglutide (Ozempic/Wegovy), which activates a single receptor (GLP-1), or tirzepatide (Mounjaro/Zepbound), which activates two (GLP-1 + GIP), retatrutide activates three metabolic receptors at once: GLP-1 slows gastric emptying, suppresses appetite, improves insulin response GIP additional insulin-sensitivity and appetite effects Glucagon boosts energy expenditure and lipolysis (this is the new mechanism) The glucagon component is what makes retatrutide unique
Expert consensus (2024 PMC review)
We can even have our back office staff to do a check
The unhealthy pancreas does not make enough intrinsic factor and deficiency ensues when pancreatitis becomes chronic
